The two main types of slowing are focal and generalized slowing. Based on previous reports, rather than taking the view PLEDs represent either an underlying ictal processor an electrographic correlate of neuronal injury, it would be more reasonable that PLEDs are considered as a dynamicpathophysiological state in which unstable neurobiological processes create an ictal-interictal continuum. EEG can provide evidence for underlying diffuse or focal cerebral dysfunction through demonstration of background slowing. PLEDs are usually seen in the context of destructive structural lesions involving the cortex. This review includes coma with epileptiform EEG pattern and its prognostic andtherapeutic implications. clature, and clinical and EEG categorization have largely arisenfromcaseseriesreports,whicharesubjecttolump-ing, splitting, and often the absence of a control popu-lation. THEORIES OF PLEDs NEUROPHYSIOLOGY Pohlmann et al (1996) PLEDs are EEG signature of a dynamic patho-physiological state in which unstable neurobiological processes create an ictal-interictal continuum. (1,2) In patients with Herpes Simplex Virus (HSV), specific findings such as the Periodic lateralized epileptic form discharges (PLEDs) are considered a specific finding on electroencephalogram (EEG). The goal of this review is to give evidence that such periodic discharges on EEG are not ictal phenomenon and justrepresent underlying acute brain damage. 1 PLEDs were found in only 0.5 of 8002 pediatric electroencephalographic (EEG) studies.2 PLEDs have been described in association with a variety of. Provided the original work is properly cited.Īlthough the pathophysiologic mechanism is unknown, there has been long-running debate on whether periodic discharges suchas periodic lateralized epileptiform discharges (PLEDs) and generalized periodic epileptiform discharges are an ictal or interictalEEG pattern. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License () which permits unrestricted non-commercial use, distribution, and reproduction in any medium, Periodic Lateralized Epileptiform Discharges Are Not IctalPhenomenon, and Just Reflect an Acute Brain DamageĬopyright © 2011 The Korean Society of Clinical Neurophysiology

Ann Clin Neurophysiol > 2011 13(1) > ArticleĪnn Clin Neurophysiol.

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